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MSC09 5100
1 University of New Mexico
Albuquerque, NM 87131-0001

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Surojit Paul, Ph.D.

Contact Information:
Deapartment of Neurology
MSC 105620
Building: BRF; Room No: 137J

Albuquerque NM 87131
spaul@salud.unm.edu

Department:
Neurology

Education:
Doctor of Philosophy :
Jadavpur University, (1995)

Interests:
The mitogen activated protein kinases (MAPKs) are expressed ubiquitously in the central nervous system. They participate in diverse physiological processes, including neuronal maturation and survival, learning and memory as well as neuronal cell death. Multiple lines of evidence strongly indicate that MAPK pathways are also involved in the pathophysiology of alzheimer’s disease, parkinson’s disease, schizophrenia and stroke. This raises the questions as to how they can participate in such diverse patho-physiological processes? Growing evidence suggests that the magnitude and duration of MAP kinase activation are important in determining a particular biological outcome. But how cells determine the duration of MAP kinase signaling is still unclear. The fact that MAPKs are activated by a single kinase but inactivated by several phosphatases, indicate that diverse signals are probably integrated at the phosphatase level. The primary goal of our laboratory is to elucidate the role of protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases in the regulation of signaling pathways in the brain and in particular the MAP kinase signaling cascades, under different patho-physiological condition.

Publications:
* 13. Surojit Paul, Kusumika Gharami, Sumantra Das, Pranab K Sarkar. Thyroid Hormone induced maturation of astrocytes is associated with the expression of new variants of vimentin and their phosphorylation. (1999) J. Neurochem 73(5), 1964-1972

* Ranjana Poddar, Surojit Paul, Sukanya Choudhury and Pranab K Sarkar. Regulation of tubulin and actin gene expression by thyroid hormone during rat brain development. (1996) Molecular Brain Research 35(1-2), 111-118

* Surojit Paul and Paul J Lombroso. Receptor and non-receptor protein tyrosine phosphatases in the nervous system. (2003) Cell Mol. Life Sci. 60(11) 2465-2482, Review

* Surojit Paul, Angus C Nairn, Ping Wang and Paul J Lombroso. Glutamate/NMDA receptor mediated activation of a protein tyrosine phosphatase, STEP, leads to the release of ERK2 through tyrosine de-phosphorylation. (2003) Nature Neurosci. 6(1) 34-42

* Surojit Paul

* Steven P Braithwaite, Surojit Paul, Angus C Nairn, Paul J Lombroso. Synaptic Platicity: One STEP at a time. (2006) Trends Neurosci. 29: 452-458

* Surojit Paul, Gretchen L Snyder, Hiasyuki Yokakura, Marina R Picciotto, Angus C Nairn and Paul J Lombroso. Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase, STEP, through a PKA-dependent pathway. (2000) J. Neurosci. 20(15), 5630-5638

* Surojit Paul, Peter Olausson, Deepa V Venkitaramani , Timothy D Moran, Irina Ruchkina, Natalie Tronson, Evan Mills, Shawn Hakim, Michael W Salter, Jane R Taylor, Paul J Lombroso. The protein tyrosine phosphatase STEP gates long-term potentiation and fear memory in the lateral amygdala. (2006) Biol Psychiatry. In press

* Eric M Snyder, Yi Nong, Claudia G Almedia, Surojit Paul, Timothy D Moran, Eun Y Choi, Angus C. Nairn, Michael W Salter, Paul J Lombroso, Gunnar K Gouras, Paul Greengard. Regulation of NMDA receptor trafficking by amyloid-?. (2005) Nature Neurosci. 6:34-42

* Surojit Paul, Kusumika Gharami, Sumantra Das, Pranab K Sarkar. Thyroid Hormone induced maturation of astrocytes is associated with the expression of new variants of vimentin and their phosphorylation. (1999) J. Neurochem 73(5), 1964-1972

* Sumantra Das and Surojit Paul. Decrease in beta-adrenargic receptors of cerebral astrocytes in hypothyroid rat brain (1994) Life Science 54(9), 621-629

* Surojit Paul, Sumantra Das, Ranjana Poddar and Pranab K Sarkar. Role of Thyroid hormone in the morphological differentiation and maturation of astrocytes: Temporal correlation with synthesis and organization of actin. (1996) Eur. J. Neurosci. 8, 2361-2370.

* Kenneth Pelkey, Rand Askalan, Surojit Paul, Tri-Hung Nguyen, Lorraine Hajdur, Michael W Salter and Paul J Lombroso. Regulation of NMDA Receptor function by Tyrosine Phosphatase STEP. (2002) Neuron 34(1), 127-138

* Surojit Paul, Sumantra Das, Pranab K Sarkar. Effect of hypothyroidism on different forms of actin in rat cerebral neuronal cultures by an improved DNAse I inhibition assay. (1992) J. Neurochem. 59(2), 701-707